LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- The G/A-455 SNP was examined in 187 centenarians (47 males and 140 females) and 201 controls (20-64 years)
- Conclusions
- No association with longevity was found
- HGNC symbol
- FGB
- Aliases
- HEL-S-78p
- Common name
- fibrinogen beta chain
- Description
- The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
- Other longevity studies of this gene
- 3
- OMIM
- 134830
- Ensembl
- ENSG00000171564
- UniProt/Swiss-Prot
- FIBB_HUMAN
- Entrez Gene
- 2244
- UniGene
- 300774
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- fgb
- Drosophila melanogaster
- CG41520
- Mus musculus
- Fgb
- Rattus norvegicus
- Fgb
Tan et al. (2001)
Other variants which are also part of this study
