LongevityMap variant
- Longevity Association
- Non-significant
- Population
- American (Caucasian)
- Study Design
- GPIa C807T SNP was examined in 2689 healthy Caucasians aged 17-39 years (n = 979; 505 males and 474 females), 40-59 years (n = 900; 526 males and 374 females), and 60-85 years (n = 810; 530 males and 280 females)
- Conclusions
- No statistically significant decrease in genotype or allele frequency was observed
- HGNC symbol
- ITGA2
- Aliases
- BR; GPIa; CD49B; HPA-5; VLA-2; VLAA2
- Common name
- integrin subunit alpha 2
- Description
- This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
- OMIM
- 192974
- Ensembl
- ENSG00000164171
- UniProt/Swiss-Prot
- ITA2_HUMAN
- Entrez Gene
- 3673
- UniGene
- 482077
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- itga2.2
- Drosophila melanogaster
- ItgalphaPS5
- Drosophila melanogaster
- ItgalphaPS4
- Drosophila melanogaster
- scb
- Mus musculus
- Itga2
- Rattus norvegicus
- Itga2
- CellAge gene expression
- This gene is present as ITGA2
Hessner et al. (2001)
Other variants which are also part of this study
