LongevityMap variant
- Longevity Association
- Significant
- Population
- Russian
- Study Design
- 5'-untranslated region (T-455C) SNP was examined in a group of 137 elderly individuals (70-106 years old)
- Conclusions
- A greater frequency of the -455C allele was demonstrated with aging
- HGNC symbol
- APOC3
- Aliases
- HALP2; APOCIII
- Common name
- apolipoprotein C3
- Description
- Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 7
- OMIM
- 107720
- Ensembl
- ENSG00000110245
- UniProt/Swiss-Prot
- A3KPE2_HUMAN
- Entrez Gene
- 345
- UniGene
- 73849
- HapMap
- View on HapMap
Homologs in model organisms
- Mus musculus
- Apoc3
- Rattus norvegicus
- Apoc3
- GenAge human genes
- This gene is present as APOC3
Anisimov et al. (2001)
Other variants which are also part of this study
