LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Italian (Northern)
- Study Design
- Deletion was examined in 94 nonagenarians and centenarians and 418 control subjects of younger age
- Conclusions
- A significant difference in the proportion of nonagenarians and centenarians homozygotes for the deletion was observed in comparison to control subjects
- Identifier
- GSTT1
- In Other Studies (IDs)
- 148 212 429
- Cytogenetic Location
- 22q11.23
- UCSC Genome Browser
- View 22q11.23 on the UCSC genome browser
Gene details
- HGNC symbol
- GSTT1
- Aliases
- Common name
- glutathione S-transferase theta 1
- Description
- The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015]
- Other longevity studies of this gene
- 3
- OMIM
- 600436
- Ensembl
- UniProt/Swiss-Prot
- A0A0G2JRN4_HUMAN
- Entrez Gene
- 2952
- UniGene
- 268573
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found