LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- A/V114 SNP was examined in 187 unselected centenarians, and 201 healthy controls aged 20-64 years (mean age 42 years)
- Conclusions
- No significant association with longevity was found
- Identifier
- 114A/V
- In Other Studies (IDs)
- 143
- Cytogenetic Location
- 1p36.22
- UCSC Genome Browser
- View 1p36.22 on the UCSC genome browser
Gene details
- HGNC symbol
- MTHFR
- Aliases
- Common name
- methylenetetrahydrofolate reductase
- Description
- The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.[provided by RefSeq, Oct 2009]
- Other longevity studies of this gene
- 16
- OMIM
- 607093
- Ensembl
- ENSG00000177000
- UniProt/Swiss-Prot
- MTHR_HUMAN
- Entrez Gene
- 4524
- UniGene
- 214142
- HapMap
- View on HapMap