LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- Intron 8 insertion 311 polymorphism was examined in 187 Danish centenarians, and 201 healthy Danish blood donors, aged 20-64 years (mean age 42 years)
- Conclusions
- No significant differences relative to longevity were found
- HGNC symbol
- PLAT
- Aliases
- TPA; T-PA
- Common name
- plasminogen activator, tissue type
- Description
- This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
- OMIM
- 173370
- Ensembl
- ENSG00000104368
- UniProt/Swiss-Prot
- B4DN26_HUMAN
- Entrez Gene
- 5327
- UniGene
- 491582
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- svh-1
- Danio rerio
- plat
- Mus musculus
- Plat
- Rattus norvegicus
- LOC100910418
- Rattus norvegicus
- Plat
- CellAge gene expression
- This gene is present as PLAT
Bladbjerg et al. (1999)
Other variants which are also part of this study
