LongevityMap variant
- Longevity Association
- Significant
- Population
- Caucasian
- Study Design
- -374T/A was investigated in subjects aged >=90 and middle-aged individuals.
- Conclusions
- Genotype AA and AT were associated with longevity in males. Allele A may have a protective role in aging.
- HGNC symbol
- AGER
- Aliases
- RAGE; SCARJ1
- Common name
- advanced glycosylation end-product specific receptor
- Description
- The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]
- OMIM
- 600214
- Ensembl
- ENSG00000204305
- UniProt/Swiss-Prot
- B4DNX3_HUMAN
- Entrez Gene
- 177
- UniGene
- 534342
- HapMap
- View on HapMap
Homologs in model organisms
- Mus musculus
- Ager
- Rattus norvegicus
- Ager
Falcone et al. (2013)
Other variants which are also part of this study
