LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Jordanian
- Study Design
- Polymorphisms were genotyped in 130 elderly subjects (57 females, mean age: 90.01 years) and 135 young control subjects (67 females, mean age: 33.43 years) for longevity association
- Conclusions
- No significant differences were found in the genotype and allele frequencies of examined SOD2 and MTHFR gene variants between the elderly group and young controls (P > 0.05), nor when each gender was considered separately (P > 0.05). SOD2 -9T/C and MTHFR 677C/T were not associated with longevity in the Jordanian population.
- HGNC symbol
- MTHFR
- Aliases
-
- Common name
- methylenetetrahydrofolate reductase
- Description
- The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.[provided by RefSeq, Oct 2009]
- Other longevity studies of this gene
- 16
- OMIM
- 607093
- Ensembl
- ENSG00000177000
- UniProt/Swiss-Prot
- MTHR_HUMAN
- Entrez Gene
- 4524
- UniGene
- 214142
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- mthf-1
- Danio rerio
- mthfr
- Drosophila melanogaster
- CG7560
- Mus musculus
- Mthfr
- Rattus norvegicus
- Mthfr
- Saccharomyces cerevisiae
- MET13
- Schizosaccharomyces pombe
- met9
Khabour et al. (2009)
Other variants which are also part of this study
