LongevityMap variant
- Longevity Association
- Significant
- Population
- American, English, Irish
- Study Design
- 10 late-onset Alzheimer's disease genes were tested for association with human aging in a dataset with 1385 samples with documented age at death (age range: 58–108 years; mean age at death: 80.2 years) using the most significant SNPs found in the previous studies
- Conclusions
- APOE locus (rs2075650) showed compelling evidence of association with human life span (p = 5.27 × 10−4)
- HGNC symbol
- TOMM40
- Aliases
- TOM40; PEREC1; C19orf1; PER-EC1; D19S1177E
- Common name
- translocase of outer mitochondrial membrane 40
- Description
- The protein encoded by this gene is localized in the outer membrane of the mitochondria. It is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for import of protein precursors into mitochondria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015]
- Other longevity studies of this gene
- 6
- OMIM
- 608061
- Ensembl
- ENSG00000130204
- UniProt/Swiss-Prot
- TOM40_HUMAN
- Entrez Gene
- 10452
- UniGene
- 655909
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- tomm-40
- Danio rerio
- tomm40l
- Danio rerio
- tomm40
- Drosophila melanogaster
- Tom40
- Drosophila melanogaster
- tomboy40
- Mus musculus
- Tomm40
- Rattus norvegicus
- Tomm40
- Saccharomyces cerevisiae
- TOM40
- CellAge gene expression
- This gene is present as TOMM40
Shi et al. (2012)
Other variants which are also part of this study
