LongevityMap variant

Entry Details

Longevity Association: Significant
Population: Danish, American
Study Design: Generalized estimating equations were used to compare the likelihood of carrying risk alleles in offspring (n = 2307) and spouse controls (n = 764) of long-lived families, adjusting for age, sex, level of education, and family membership
Conclusions: The likelihood of carrying an APOE ɛ4 allele or a G allele in rs2075650 was lower (odds ratio [OR], 0.75; p = 0.005 and OR, 0.70; p = 0.002) and the likelihood of carrying an APOE ɛ2 allele was higher (OR, 1.5; p = 0.007) among family members in the offspring generation than among their spouse controls. Both reduction in the frequency of the ε4 allele and increase in the frequency of the ε2 allele contribute to longevity.

HGNC symbol: TOMM40
Aliases: TOM40; PEREC1; C19orf1; PER-EC1; D19S1177E
Common name: translocase of outer mitochondrial membrane 40
Description: The protein encoded by this gene is localized in the outer membrane of the mitochondria. It is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for import of protein precursors into mitochondria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015]
Other longevity studies of this gene: 6
OMIM: 608061
Ensembl: ENSG00000130204
UniProt/Swiss-Prot: TOM40_HUMAN
Entrez Gene: 10452
UniGene: 655909
HapMap: View on HapMap

CellAge gene expression

Schupf et al. (2013)