LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Spanish
- Study Design
- The association between five common polymorphisms in genes of this pathway and extreme longevity were examined using a case (107 centenarian, 100–111 years, 89 female)-control (284 young adults, ≤50 years, 150 female) design.
- Conclusions
- The studied genetic variants of the PPARD-PPARGC1A-NRF-TFAM pathway were not associated with extreme longevity. A marginal association could exist for rs1937 in TFAM (p=0.003).
- HGNC symbol
- TFAM
- Aliases
- TCF6; MTTF1; MTTFA; TCF6L1; TCF6L2; TCF6L3; MTDPS15
- Common name
- transcription factor A, mitochondrial
- Description
- This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
- Other longevity studies of this gene
- 6
- OMIM
- 600438
- Ensembl
- ENSG00000108064
- UniProt/Swiss-Prot
- E5KSU5_HUMAN
- Entrez Gene
- 7019
- UniGene
- 594250
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- tfam
- Drosophila melanogaster
- TFAM
- Mus musculus
- Tfam
- Rattus norvegicus
- Tfam
- CellAge gene expression
- This gene is present as TFAM
Santiago et al. (2013)
Other variants which are also part of this study
