LongevityMap variant

Entry Details

Longevity Association
Significant
Population
Japanese
Study Design
11 Japanese centenarians and 43 controls were sequenced to identify the substitution differences between centenarians and controls. Then the identified variants were examined in 37 centenarians and 252 healthy controls.
Conclusions
The frequency of Mt5178A was significantly higher in centenarians (23/37, 62%) than in blood donors (114/252, 45% p=0.04, odds ratio 1.99). Mt5178A was related to longevity. Mt5178C carriers were more susceptible to adult-onset diseases than those with Mt5178A.
Identifier
Mt5178A/C
Cytogenetic Location
MT
UCSC Genome Browser
View MT on the UCSC genome browser

Gene details

HGNC symbol
ND2
Aliases
MTND2 
Common name
NADH dehydrogenase subunit 2 
Description
Other longevity studies of this gene
1
OMIM
516001
Ensembl
UniProt/Swiss-Prot
NU2M_HUMAN
Entrez Gene
4536
UniGene
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
mt-nd2
Drosophila melanogaster
mt:ND2
Mus musculus
mt-Nd2
Rattus norvegicus
Mt-nd2

References

Tanaka et al. (1998)

Other variants which are also part of this study