LongevityMap variant
- Longevity Association
- Significant
- Population
- Japanese
- Study Design
- 11 Japanese centenarians and 43 controls were sequenced to identify the substitution differences between centenarians and controls. Then the identified variants were examined in 37 centenarians and 252 healthy controls.
- Conclusions
- The frequency of Mt5178A was significantly higher in centenarians (23/37, 62%) than in blood donors (114/252, 45% p=0.04, odds ratio 1.99). Mt5178A was related to longevity. Mt5178C carriers were more susceptible to adult-onset diseases than those with Mt5178A.
- HGNC symbol
- ND2
- Aliases
- MTND2
- Common name
- NADH dehydrogenase subunit 2
- Description
- Other longevity studies of this gene
- 1
- OMIM
- 516001
- Ensembl
- UniProt/Swiss-Prot
- NU2M_HUMAN
- Entrez Gene
- 4536
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- mt-nd2
- Drosophila melanogaster
- mt:ND2
- Mus musculus
- mt-Nd2
- Rattus norvegicus
- Mt-nd2
Tanaka et al. (1998)
Other variants which are also part of this study
