LongevityMap variant

Entry Details

Longevity Association: Significant
Population: Italian (Southern)
Study Design: A sample of 277 unrelated individuals (>70 years old, mean age, 82.9) was recruited in 2000 and genotyped. On the basis of mortality data collected in 2009, the sample was divided into two groups of subjects surviving over 90 years (long-lived) or not (controls).
Conclusions: The frequency of the PPARG Pro/Ala genotype was significantly higher in the sample of male subjects who died before 90 years of age than in the long-lived, suggesting that carrying the PPARG Pro/Ala genotype may prevent the attainment of advanced age in men only

HGNC symbol: PPARG
Aliases: GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma
Common name: peroxisome proliferator activated receptor gamma
Description: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 3
OMIM: 601487
Ensembl: ENSG00000132170
UniProt/Swiss-Prot: D2KUA6_HUMAN
Entrez Gene: 5468
UniGene: 162646
HapMap: View on HapMap

GenAge model organism genes

GenAge human genes

CellAge

Corbo et al. (2013)