LongevityMap variant
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study using 1,471 genotyped participants from the Framingham Heart Study, of which 1,173 individuals had known lifespans, plus 517 individuals from the Offspring cohort for validating connections between longevity and genetic variants
- Conclusions
- A total of 27 SNPs, including in CDH4, SVEP1, CACNA1C, CARS, STK24, C7orf50, PARVG, NCAM2, PPP2R2C, NLRC5, BTBD9, RAC2, TGFA, KIAA0649, ABCC4, CLSTN2, FAM19A5 and RUNX3, were identified at the intersection of various statistical procedures
- HGNC symbol
- NLRC5
- Aliases
- NOD4; NOD27; CLR16.1
- Common name
- NLR family CARD domain containing 5
- Description
- This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]
- OMIM
- 613537
- Ensembl
- ENSG00000140853
- UniProt/Swiss-Prot
- NLRC5_HUMAN
- Entrez Gene
- 84166
- UniGene
- 528836
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- si:ch211-122c9.5
- Mus musculus
- Nlrc5
- Rattus norvegicus
- Nlrc5
Yashin et al. (2012)
Other variants which are also part of this study