LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
- Conclusions
- No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.
- HGNC symbol
- SOD1
- Aliases
- ALS; SOD; ALS1; IPOA; hSod1; HEL-S-44; homodimer
- Common name
- superoxide dismutase 1
- Description
- The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 7
- OMIM
- 147450
- Ensembl
- ENSG00000142168
- UniProt/Swiss-Prot
- SODC_HUMAN
- Entrez Gene
- 6647
- UniGene
- 443914
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- sod-4
- Danio rerio
- sod1
- Drosophila melanogaster
- Sod
- Mus musculus
- Sod1
- Rattus norvegicus
- Sod1
- Saccharomyces cerevisiae
- SOD1
- Schizosaccharomyces pombe
- sod1
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as SOD1
- A homolog of this gene for Drosophila melanogaster is present as Sod
- GenAge human genes
- This gene is present as SOD1
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as SOD1
- CellAge
- This gene is present as SOD1
Dato et al. (2014)
Other variants which are also part of this study