LongevityMap variant
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study using 1,471 genotyped participants from the Framingham Heart Study, of which 1,173 individuals had known lifespans, plus 517 individuals from the Offspring cohort for validating connections between longevity and genetic variants
- Conclusions
- A total of 27 SNPs, including in CDH4, SVEP1, CACNA1C, CARS, STK24, C7orf50, PARVG, NCAM2, PPP2R2C, NLRC5, BTBD9, RAC2, TGFA, KIAA0649, ABCC4, CLSTN2, FAM19A5 and RUNX3, were identified at the intersection of various statistical procedures
- HGNC symbol
- CDH4
- Aliases
- CAD4; RCAD; R-CAD
- Common name
- cadherin 4
- Description
- This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
- OMIM
- 603006
- Ensembl
- ENSG00000179242
- UniProt/Swiss-Prot
- CADH4_HUMAN
- Entrez Gene
- 1002
- UniGene
- 473231
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- cdh4
- Mus musculus
- Cdh4
- Rattus norvegicus
- Cdh4
Yashin et al. (2012)
Other variants which are also part of this study
