LongevityMap variant
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- rs2075650, in a TOMM40 intron but a proxy of SNPs defining APOE alleles, was highly significant for exceptional longevity
- HGNC symbol
- TOMM40
- Aliases
- TOM40; PEREC1; C19orf1; PER-EC1; D19S1177E
- Common name
- translocase of outer mitochondrial membrane 40
- Description
- The protein encoded by this gene is localized in the outer membrane of the mitochondria. It is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for import of protein precursors into mitochondria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015]
- Other longevity studies of this gene
- 6
- OMIM
- 608061
- Ensembl
- ENSG00000130204
- UniProt/Swiss-Prot
- TOM40_HUMAN
- Entrez Gene
- 10452
- UniGene
- 655909
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- tomm-40
- Danio rerio
- tomm40l
- Danio rerio
- tomm40
- Drosophila melanogaster
- Tom40
- Drosophila melanogaster
- tomboy40
- Mus musculus
- Tomm40
- Rattus norvegicus
- Tomm40
- Saccharomyces cerevisiae
- TOM40
- CellAge gene expression
- This gene is present as TOMM40
Sebastiani et al. (2012)
Other variants which are also part of this study
