LongevityMap variant
- Longevity Association
- Significant
- Population
- European
- Study Design
- Genome-wide linkage scan in 2118 European nonagenarian sibships and younger controls from various European studies followed by genome-wide association study in a subgroup of 1228 unrelated nonagenarian and 1907 geographically matched controls
- Conclusions
- Only one SNP (rs4420638 in the TOMM40/APOE/APOC1 gene locus) was significantly associated with longevity in the GWAS
- HGNC symbol
- APOC1
- Aliases
- Apo-CI; ApoC-I; apo-CIB; apoC-IB
- Common name
- apolipoprotein C1
- Description
- This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016]
- Other longevity studies of this gene
- 3
- OMIM
- 107710
- Ensembl
- ENSG00000130208
- UniProt/Swiss-Prot
- A0A024R0T8_HUMAN
- Entrez Gene
- 341
- UniGene
- 110675
- HapMap
- View on HapMap
Homologs in model organisms
- Mus musculus
- Apoc1
- Rattus norvegicus
- Apoc1
- Rattus norvegicus
- LOC100910181
- Rattus norvegicus
- Apoc1
- Rattus norvegicus
- Apoc1
- CellAge gene expression
- This gene is present as APOC1
Beekman et al. (2013)
Other variants which are also part of this study