LongevityMap variant
- Longevity Association
- Significant
- Population
- Danish
- Study Design
- Alleles in candidate pathways (GH/IGF1 signaling, DNA damage signaling and repair and pro/antioxidants) were investigated for association with longevity in 1089 oldest-old (age 92-93) and 736 middle-aged Danes
- Conclusions
- Six SNPs (in TNXRD1, XDH, GHRL, MLH1, H2AFX, XRCC5) were associated with mortality in late life after correction for multiple hypothesis testing. No replications were observed in German and Dutch populations.
- HGNC symbol
- XRCC5
- Aliases
- KU80; KUB2; Ku86; NFIV; KARP1; KARP-1
- Common name
- X-ray repair cross complementing 5
- Description
- The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 21
- OMIM
- 194364
- Ensembl
- ENSG00000079246
- UniProt/Swiss-Prot
- XRCC5_HUMAN
- Entrez Gene
- 7520
- UniGene
- 388739
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- xrcc5
- Drosophila melanogaster
- Ku80
- Mus musculus
- Xrcc5
- Rattus norvegicus
- Xrcc5
- Schizosaccharomyces pombe
- pku80
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Xrcc5
- GenAge human genes
- This gene is present as XRCC5
Soerensen et al. (2012)
Other variants which are also part of this study
