LongevityMap variant

Entry Details

Longevity Association
Significant
Population
Danish
Study Design
Alleles in candidate pathways (GH/IGF1 signaling, DNA damage signaling and repair and pro/antioxidants) were investigated for association with longevity in 1089 oldest-old (age 92-93) and 736 middle-aged Danes
Conclusions
Six SNPs (in TNXRD1, XDH, GHRL, MLH1, H2AFX, XRCC5) were associated with mortality in late life after correction for multiple hypothesis testing. No replications were observed in German and Dutch populations.
Identifier
rs2509049
In Other Studies (IDs)
3184
Cytogenetic Location
11q23.3
UCSC Genome Browser
View 11q23.3 on the UCSC genome browser

Gene details

HGNC symbol
H2AFX
Aliases
H2AX; H2A.X; H2A/X 
Common name
H2A histone family member X 
Description
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Oct 2015]
Other longevity studies of this gene
1
OMIM
601772
Ensembl
ENSG00000188486
UniProt/Swiss-Prot
H2AX_HUMAN
Entrez Gene
3014
UniGene
477879
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
zgc:195633
Danio rerio
zgc:110434
Danio rerio
zgc:165551
Danio rerio
si:ch73-368j24.15
Danio rerio
zgc:101846
Danio rerio
zgc:165551
Danio rerio
h2afx
Danio rerio
si:ch1073-159d7.9
Danio rerio
zgc:110434
Danio rerio
zgc:195633
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33865
Mus musculus
H2afx
Rattus norvegicus
H2afx
Saccharomyces cerevisiae
HTA1

In other databases

GenAge human genes
  • This gene is present as H2AFX
CellAge gene expression
  • This gene is present as H2AFX

References

Soerensen et al. (2012)

Other variants which are also part of this study