LongevityMap variant
- Longevity Association
- Significant
- Population
- Danish
- Study Design
- Alleles in candidate pathways (GH/IGF1 signaling, DNA damage signaling and repair and pro/antioxidants) were investigated for association with longevity in 1089 oldest-old (age 92-93) and 736 middle-aged Danes
- Conclusions
- Six SNPs (in TNXRD1, XDH, GHRL, MLH1, H2AFX, XRCC5) were associated with mortality in late life after correction for multiple hypothesis testing. No replications were observed in German and Dutch populations.
- HGNC symbol
- H2AFX
- Aliases
- H2AX; H2A.X; H2A/X
- Common name
- H2A histone family member X
- Description
- Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Oct 2015]
- Other longevity studies of this gene
- 1
- OMIM
- 601772
- Ensembl
- ENSG00000188486
- UniProt/Swiss-Prot
- H2AX_HUMAN
- Entrez Gene
- 3014
- UniGene
- 477879
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- zgc:195633
- Danio rerio
- zgc:110434
- Danio rerio
- zgc:165551
- Danio rerio
- si:ch73-368j24.15
- Danio rerio
- zgc:101846
- Danio rerio
- zgc:165551
- Danio rerio
- h2afx
- Danio rerio
- si:ch1073-159d7.9
- Danio rerio
- zgc:110434
- Danio rerio
- zgc:195633
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33865
- Mus musculus
- H2afx
- Rattus norvegicus
- H2afx
- Saccharomyces cerevisiae
- HTA1
- GenAge human genes
- This gene is present as H2AFX
- CellAge gene expression
- This gene is present as H2AFX
Soerensen et al. (2012)
Other variants which are also part of this study