LongevityMap variant
- Longevity Association
- Significant
- Population
- Danish
- Study Design
- Alleles in candidate pathways (GH/IGF1 signaling, DNA damage signaling and repair and pro/antioxidants) were investigated for association with longevity in 1089 oldest-old (age 92-93) and 736 middle-aged Danes
- Conclusions
- Eleven SNPs (in GSR, KL, GHRHR, INS, GHSR, IGF2R, RAD52, WRN, RAD23B, POLB and NTLH1) were associated with longevity after correction for multiple hypothesis testing. No replications were observed in German and Dutch populations.
- HGNC symbol
- WRN
- Aliases
- RECQ3; RECQL2; RECQL3
- Common name
- Werner syndrome RecQ like helicase
- Description
- This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 25
- OMIM
- 604611
- Ensembl
- ENSG00000165392
- UniProt/Swiss-Prot
- Q59F09_HUMAN
- Entrez Gene
- 7486
- UniGene
- 632050
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- wrn-1
- Danio rerio
- wrn
- Mus musculus
- Wrn
- Rattus norvegicus
- Wrn
- Saccharomyces cerevisiae
- SGS1
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as SGS1
- GenAge human genes
- This gene is present as WRN
- CellAge
- This gene is present as WRN
Soerensen et al. (2012)
Other variants which are also part of this study