LongevityMap variant
- Longevity Association
- Significant
- Population
- Danish
- Study Design
- Alleles in candidate pathways (GH/IGF1 signaling, DNA damage signaling and repair and pro/antioxidants) were investigated for association with longevity in 1089 oldest-old (age 92-93) and 736 middle-aged Danes
- Conclusions
- Eleven SNPs (in GSR, KL, GHRHR, INS, GHSR, IGF2R, RAD52, WRN, RAD23B, POLB and NTLH1) were associated with longevity after correction for multiple hypothesis testing. No replications were observed in German and Dutch populations.
- HGNC symbol
- GHRHR
- Aliases
- GRFR; GHRFR; IGHD1B
- Common name
- growth hormone releasing hormone receptor
- Description
- This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010]
- Other longevity studies of this gene
- 2
- OMIM
- 139191
- Ensembl
- ENSG00000106128
- UniProt/Swiss-Prot
- A0A090N8Y6_HUMAN
- Entrez Gene
- 2692
- UniGene
- 767
- HapMap
- View on HapMap
Homologs in model organisms
- Mus musculus
- Ghrhr
- Rattus norvegicus
- Ghrhr
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Ghrhr
- GenAge human genes
- This gene is present as GHRHR
Soerensen et al. (2012)
Other variants which are also part of this study
