LongevityMap variant
- Longevity Association
- Significant
- Population
- Danish
- Study Design
- Alleles in candidate pathways (GH/IGF1 signaling, DNA damage signaling and repair and pro/antioxidants) were investigated for association with longevity in 1089 oldest-old (age 92-93) and 736 middle-aged Danes
- Conclusions
- Eleven SNPs (in GSR, KL, GHRHR, INS, GHSR, IGF2R, RAD52, WRN, RAD23B, POLB and NTLH1) were associated with longevity after correction for multiple hypothesis testing. No replications were observed in German and Dutch populations.
- HGNC symbol
- KL
- Aliases
-
- Common name
- klotho
- Description
- This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 6
- OMIM
- 604824
- Ensembl
- ENSG00000133116
- UniProt/Swiss-Prot
- KLOT_HUMAN
- Entrez Gene
- 9365
- UniGene
- 524953
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- klo-2
- Caenorhabditis elegans
- klo-1
- Danio rerio
- kl
- Mus musculus
- Kl
- Rattus norvegicus
- Kl
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Kl
- A homolog of this gene for Caenorhabditis elegans is present as klo-1
- A homolog of this gene for Caenorhabditis elegans is present as klo-2
- GenAge human genes
- This gene is present as KL
- CellAge
- This gene is present as KL
Soerensen et al. (2012)
Other variants which are also part of this study
