LongevityMap variant
- Longevity Association
- Non-significant
- Population
- American (Caucasian)
- Study Design
- 224 nonagenarian cases (84 male, 140 female, 90- 103 y) and 293 young controls (100 male, 193 female, 21- 59 y) from the Louisiana Healthy Aging Study were examined for longevity association study. Then, 170 subjects(25 male, 145 female, ≥98 y) and 220 young controls (84 male, 136 female, 20–59 y) from the Georgia Centenarian Study were examined to replicate the results.
- Conclusions
- rs132793 in XRCC6 had significant effect on telomere length, but it was not associated with longevity
- HGNC symbol
- XRCC6
- Aliases
- ML8; KU70; TLAA; CTC75; CTCBF; G22P1
- Common name
- X-ray repair cross complementing 6
- Description
- The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]
- OMIM
- 152690
- Ensembl
- ENSG00000196419
- UniProt/Swiss-Prot
- A0A024R1N4_HUMAN
- Entrez Gene
- 2547
- UniGene
- 292493
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- cku-70
- Danio rerio
- xrcc6
- Drosophila melanogaster
- Irbp
- Mus musculus
- Xrcc6
- Rattus norvegicus
- Xrcc6
- Saccharomyces cerevisiae
- YKU70
- Schizosaccharomyces pombe
- pku70
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as cku-70
- A homolog of this gene for Mus musculus is present as Xrcc6
- A homolog of this gene for Saccharomyces cerevisiae is present as YKU70
- GenAge human genes
- This gene is present as XRCC6
Kim et al. (2012)
Other variants which are also part of this study
