LongevityMap variant
- Longevity Association
- Non-significant
- Population
- French
- Study Design
- Glutamine (CAG) to histidine (CAT) substitution at codon 360 was examined in 120 Alzheimer patients (88 females, 32 males) and 119 presumed-healthy elderly subjects (62 females, 57 males)
- Conclusions
- The frequency of apoAIV alleles was not significantly different between Alzheimer patients and the elderly control group. However, in both groups, apoAIV (360:His) allele frequency was higher than in the general population.
- HGNC symbol
- APOA4
- Aliases
-
- Common name
- apolipoprotein A4
- Description
- Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 2
- OMIM
- 107690
- Ensembl
- ENSG00000110244
- UniProt/Swiss-Prot
- Entrez Gene
- 337
- UniGene
- 1247
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- apoa4b.2
- Danio rerio
- apoa4b.3
- Danio rerio
- apoa4a
- Danio rerio
- apoa4b.1
- Mus musculus
- Apoa4
- Rattus norvegicus
- Apoa4
Merched et al. (1998)
Other variants which are also part of this study
