LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Ashkenazi Jewish
- Study Design
- TSH heritability, its distribution, and association with SNPs in the TSH-B and TSHR genes was determined in Ashkenazi Jewish centenarians (n = 232; median age, 97 yr), their offspring (n = 366; median age, 69 yr), and age-matched controls without familial longevity (n = 163; median age, 70 yr)
- Conclusions
- The SNPs in TSHB did not show significant changes between cases and control
- HGNC symbol
- TSHB
- Aliases
- TSH-B; TSH-BETA
- Common name
- thyroid stimulating hormone beta
- Description
- The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
- OMIM
- 188540
- Ensembl
- ENSG00000134200
- UniProt/Swiss-Prot
- TSHB_HUMAN
- Entrez Gene
- 7252
- UniGene
- 406687
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- tshba
- Mus musculus
- Tshb
- Rattus norvegicus
- Tshb
Atzmon et al. (2009)
Other variants which are also part of this study
