LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: German
Study Design: The functional polymorphism Asp299Gly in the TLR4 gene was studied in 273 long-lived men (95-107 years), 606 male early-onset myocardial infarction patients and 594 appropriate controls from Germany
Conclusions: No noteworthy influence of the TLR4 polymorphism upon human longevity was found

HGNC symbol: TLR4
Aliases: TOLL; CD284; TLR-4; ARMD10
Common name: toll like receptor 4
Description: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Other longevity studies of this gene: 1
OMIM: 603030
Ensembl: ENSG00000136869
UniProt/Swiss-Prot: TLR4_HUMAN
Entrez Gene: 7099
UniGene: 174312
HapMap: View on HapMap

Nebel et al. (2007)