LongevityMap variant

Entry Details

Longevity Association
Non-significant
Population
Italian (Southern)
Study Design
A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
Conclusions
After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
Identifier
rs12013673
In Other Studies (IDs)
1628
Cytogenetic Location
Xq13.1
UCSC Genome Browser
View Xq13.1 on the UCSC genome browser

Gene details

HGNC symbol
FOXO4
Aliases
AFX; AFX1; MLLT7 
Common name
forkhead box O4 
Description
This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Other longevity studies of this gene
5
OMIM
300033
Ensembl
ENSG00000184481
UniProt/Swiss-Prot
FOXO4_HUMAN
Entrez Gene
4303
UniGene
584654
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
daf-16
Danio rerio
foxo4
Drosophila melanogaster
foxo
Mus musculus
Foxo4
Rattus norvegicus
Foxo4
Saccharomyces cerevisiae
HCM1
Schizosaccharomyces pombe
sep1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as daf-16
  • A homolog of this gene for Drosophila melanogaster is present as foxo
  • A homolog of this gene for Saccharomyces cerevisiae is present as HCM1
GenAge human genes
  • This gene is present as FOXO4
GenDR gene manipulations
  • A homolog of this gene for Drosophila melanogaster is present as foxo
  • A homolog of this gene for Caenorhabditis elegans is present as daf-16
CellAge
  • This gene is present as FOXO4

References

Di Cianni et al. (2013)

Other variants which are also part of this study