LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Spanish
- Study Design
- The enzymatic polymorphism was examined in 41 nonagenarians (10 males, mean age 92.2 years, range 90-98) free of known malignancies or neurodegenerative diseases and in control groups comprised of 137 (116 males, mean age 32 years)
- Conclusions
- No association with longevity was found
- HGNC symbol
- CYP2E1
- Aliases
- CPE1; CYP2E; P450-J; P450C2E
- Common name
- cytochrome P450 family 2 subfamily E member 1
- Description
- This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
- OMIM
- 124040
- Ensembl
- ENSG00000130649
- UniProt/Swiss-Prot
- CP2E1_HUMAN
- Entrez Gene
- 1571
- UniGene
- 12907
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- si:zfos-411a11.2
- Danio rerio
- cyp2y3
- Mus musculus
- Cyp2e1
- Rattus norvegicus
- Cyp2e1
- GenDR gene expression
- A homolog of this gene for Mus musculus is present as Cyp2e1
Agúndez et al. (1997)
Other variants which are also part of this study
