LongevityMap variant
- Longevity Association
- Non-significant
- Population
- English
- Study Design
- [GAPyA]n microsatellite located 120 kb 5' of XRCC5 was examined in a cohort of newborns (n=290) and a retired population (average age at sampling 70.02 years; n=430)
- Conclusions
- No evidence of association with longevity was found
- HGNC symbol
- XRCC5
- Aliases
- KU80; KUB2; Ku86; NFIV; KARP1; KARP-1
- Common name
- X-ray repair cross complementing 5
- Description
- The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 21
- OMIM
- 194364
- Ensembl
- ENSG00000079246
- UniProt/Swiss-Prot
- XRCC5_HUMAN
- Entrez Gene
- 7520
- UniGene
- 388739
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- xrcc5
- Drosophila melanogaster
- Ku80
- Mus musculus
- Xrcc5
- Rattus norvegicus
- Xrcc5
- Schizosaccharomyces pombe
- pku80
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Xrcc5
- GenAge human genes
- This gene is present as XRCC5
Wilding et al. (2006)
Other variants which are also part of this study
