LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: American (Caucasian and African–American), Ashkenazi Jewish
Study Design: A panel of 477 tag SNPs across 87 candidate genes was screened in >5000 older participants from the population-based Cardiovascular Health Study (CHS). Then, the significant results were validated in Ashkenazi Jews cohort and Study of Osteoporotic Fractures (SOF) cohort.
Conclusions: Although baseline IL-6 concentration was a strong predictor of mortality, and IL6R alleles were associated with IL-6, there was no evidence of association between IL6R alleles and longevity

HGNC symbol: IL6R
Aliases: IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1
Common name: interleukin 6 receptor
Description: This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]
Other longevity studies of this gene: 14
OMIM: 147880
Ensembl: ENSG00000160712
UniProt/Swiss-Prot: A0A087WTB5_HUMAN
Entrez Gene: 3570
UniGene: 135087
HapMap: View on HapMap