LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Italian (Central and Southern)
- Study Design
- -330T/G SNP was examined in 168 centenarians and 214 control subjects matched for age and ancestry
- Conclusions
- No significant difference between centenarians and controls was observed
- HGNC symbol
- IL2
- Aliases
- IL-2; TCGF; lymphokine
- Common name
- interleukin 2
- Description
- The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 2
- OMIM
- 147680
- Ensembl
- ENSG00000109471
- UniProt/Swiss-Prot
- IL2_HUMAN
- Entrez Gene
- 3558
- UniGene
- 89679
- HapMap
- View on HapMap
Homologs in model organisms
- Mus musculus
- Il2
- Rattus norvegicus
- Il2
- GenAge human genes
- This gene is present as IL2
Scola et al. (2005)
Other variants which are also part of this study
