LongevityMap variant
- Longevity Association
- Non-significant
- Population
- American (Caucasian and African–American), Ashkenazi Jewish
- Study Design
- A panel of 477 tag SNPs across 87 candidate genes was screened in >5000 older participants from the population-based Cardiovascular Health Study (CHS). Then, the significant results were validated in Ashkenazi Jews cohort and Study of Osteoporotic Fractures (SOF) cohort.
- Conclusions
- The minor allele of PARP1 rs1805415 was nominally associated with decreased longevity (P = 0.001) and higher IL-6 concentration. The results were replicated in Ashkenazi Jews cohort (P = 0.04), yet failed in the SOF cohort. A pooled analysis revealed a borderline significant association (P = 0.07). rs1805415 is in strong LD with rs1136410.
- HGNC symbol
- PARP1
- Aliases
- PARP; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT; 1; pADPRT-1
- Common name
- poly(ADP-ribose) polymerase 1
- Description
- This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 15
- OMIM
- 173870
- Ensembl
- ENSG00000143799
- UniProt/Swiss-Prot
- A0A024R3T8_HUMAN
- Entrez Gene
- 142
- UniGene
- 177766
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- parp-1
- Danio rerio
- parp1
- Drosophila melanogaster
- Parp
- Mus musculus
- Parp1
- Rattus norvegicus
- Parp1
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Parp1
- A homolog of this gene for Caenorhabditis elegans is present as pme-1
- GenAge human genes
- This gene is present as PARP1
- CellAge
- This gene is present as PARP1
- CellAge gene expression
- This gene is present as PARP1
Walston et al. (2009)
Other variants which are also part of this study
