LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: Mexican
Study Design: A total of 71 healthy elders were studied, age ranged from 80 to 96 years (mean 86.2 years). The control samples were obtained from 99 young (from 21 - 54 years; mean 35.2 years) healthy individuals unrelated to elders.
Conclusions: The frequencies of the alleles tested were not statistically different among groups

HGNC symbol: HLA-DQA1
Aliases: DQ-A1; CELIAC1; HLA-DQA
Common name: major histocompatibility complex, class II, DQ alpha 1
Description: HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 4
OMIM: 146880
Ensembl: ENSG00000196735
UniProt/Swiss-Prot: A0A173ADG5_HUMAN
Entrez Gene: 3117
UniGene: 387679
HapMap: View on HapMap

Soto-Vega et al. (2005)