LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: American (Caucasian)
Study Design: Genotypes for -455 G/A were studied in 2224 men and women aged 65 years and older at baseline
Conclusions: During 10 years of follow-up, no association with survival was found

HGNC symbol: FGB
Aliases: HEL-S-78p
Common name: fibrinogen beta chain
Description: The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Other longevity studies of this gene: 3
OMIM: 134830
Ensembl: ENSG00000171564
UniProt/Swiss-Prot: FIBB_HUMAN
Entrez Gene: 2244
UniGene: 300774
HapMap: View on HapMap