LongevityMap variant

Entry Details

Longevity Association
Significant
Population
American (Caucasian)
Study Design
Genotypes were studied in 2224 men and women aged 65 or older at baseline
Conclusions
During 10 years of follow-up, men with the -438 A/A genotype had decreased mortality due to all causes, and lived, on average, longer than men with the -438 G allele. The effects of -438 G/A in women were smaller and not statistically significant.
Identifier
-438A/G
Cytogenetic Location
13q14.13
UCSC Genome Browser
View 13q14.13 on the UCSC genome browser

Gene details

HGNC symbol
CPB2
Aliases
CPU; PCPB; TAFI 
Common name
carboxypeptidase B2 
Description
Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
OMIM
603101
Ensembl
ENSG00000080618
UniProt/Swiss-Prot
A0A087WSY5_HUMAN
Entrez Gene
1361
UniGene
512937
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
Y47G6A.19
Caenorhabditis elegans
T06A4.1
Caenorhabditis elegans
T06A4.3
Caenorhabditis elegans
Y18H1A.9
Caenorhabditis elegans
suro-1
Caenorhabditis elegans
ZC434.9
Caenorhabditis elegans
F02D8.4
Caenorhabditis elegans
W01A8.6
Caenorhabditis elegans
Y59C2A.1
Danio rerio
cpb2
Drosophila melanogaster
CG8539
Drosophila melanogaster
CG4408
Drosophila melanogaster
CG32379
Drosophila melanogaster
CG3097
Drosophila melanogaster
CG8560
Drosophila melanogaster
CG7025
Drosophila melanogaster
CG4017
Drosophila melanogaster
CG17633
Drosophila melanogaster
CG18585
Drosophila melanogaster
CG8945
Drosophila melanogaster
CG42264
Drosophila melanogaster
CG3108
Drosophila melanogaster
CG18417
Drosophila melanogaster
CG2915
Drosophila melanogaster
CG8563
Drosophila melanogaster
CG12374
Drosophila melanogaster
CG8564
Drosophila melanogaster
CG8562
Drosophila melanogaster
CG14820
Mus musculus
Cpb2
Rattus norvegicus
Cpb2
Saccharomyces cerevisiae
ECM14

References

Reiner et al. (2005)

Other variants which are also part of this study