LongevityMap variant

Entry Details

Longevity Association: Significant
Population: American (Caucasian)
Study Design: Genotypes were studied in 2224 men and women aged 65 or older at baseline
Conclusions: During 10 years of follow-up, men with the -438 A/A genotype had decreased mortality due to all causes, and lived, on average, longer than men with the -438 G allele. The effects of -438 G/A in women were smaller and not statistically significant.

HGNC symbol: CPB2
Aliases: CPU; PCPB; TAFI
Common name: carboxypeptidase B2
Description: Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
OMIM: 603101
Ensembl: ENSG00000080618
UniProt/Swiss-Prot: A0A087WSY5_HUMAN
Entrez Gene: 1361
UniGene: 512937
HapMap: View on HapMap

Reiner et al. (2005)