LongevityMap variant
- Longevity Association
- Non-significant
- Population
- English (Cambridge)
- Study Design
- The 677C/T SNP was examined in 182 women and 100 men aged > 84 years and in 100 boys and 100 girls younger than 17 years
- Conclusions
- MTHFR allele and genotype frequencies were similar in the elderly and young populations
- HGNC symbol
- MTHFR
- Aliases
-
- Common name
- methylenetetrahydrofolate reductase
- Description
- The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.[provided by RefSeq, Oct 2009]
- Other longevity studies of this gene
- 16
- OMIM
- 607093
- Ensembl
- ENSG00000177000
- UniProt/Swiss-Prot
- MTHR_HUMAN
- Entrez Gene
- 4524
- UniGene
- 214142
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- mthf-1
- Danio rerio
- mthfr
- Drosophila melanogaster
- CG7560
- Mus musculus
- Mthfr
- Rattus norvegicus
- Mthfr
- Saccharomyces cerevisiae
- MET13
- Schizosaccharomyces pombe
- met9
Galinsky et al. (1997)
Other variants which are also part of this study
