LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Japanese
- Study Design
- 3 intronic polymorphisms were examined in 122 Japanese semisupercentenarians (older than 105, 107 female, 15 male, mean age 106.8 years) and 122 healthy younger controls (105 female, 17 male, mean age 33.33)
- Conclusions
- No significant differences relative to longevity were found
- HGNC symbol
- FOXO1
- Aliases
- FKH1; FKHR; FOXO1A
- Common name
- forkhead box O1
- Description
- This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 30
- OMIM
- 136533
- Ensembl
- ENSG00000150907
- UniProt/Swiss-Prot
- FOXO1_HUMAN
- Entrez Gene
- 2308
- UniGene
- 370666
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- daf-16
- Danio rerio
- foxo1a
- Danio rerio
- foxo1b
- Drosophila melanogaster
- foxo
- Mus musculus
- Foxo1
- Rattus norvegicus
- Foxo1
- Saccharomyces cerevisiae
- HCM1
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as daf-16
- A homolog of this gene for Drosophila melanogaster is present as foxo
- A homolog of this gene for Saccharomyces cerevisiae is present as HCM1
- GenAge human genes
- This gene is present as FOXO1
- GenDR gene manipulations
- A homolog of this gene for Drosophila melanogaster is present as foxo
- A homolog of this gene for Caenorhabditis elegans is present as daf-16
- CellAge
- This gene is present as FOXO1
Kojima et al. (2004)
Other variants which are also part of this study
