LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: Danish
Study Design: The -308 G/A SNP was examined in 122 centenarians, 174 octogenarians and 47 healthy volunteers aged 18 to 30
Conclusions: The distribution of TNF-308 genotypes was not different across the three different age groups, but the GA genotype was associated with decreased prevalence of dementia in centenarians. The few centenarians with AA carrier status had higher mortality risk and tended to show higher plasma levels of TNF-alpha.

HGNC symbol: TNF
Aliases: DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha
Common name: tumor necrosis factor
Description: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 13
OMIM: 191160
Ensembl: ENSG00000232810
UniProt/Swiss-Prot: Q5STB3_HUMAN
Entrez Gene: 7124
UniGene: 241570
HapMap: View on HapMap

GenAge human genes

Bruunsgaard et al. (2004)