LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- The -262C/T polymorphism was examined in 2223 Danish individuals aged 45-93 years
- Conclusions
- The -262C/T polymorphism was not associated with survival
- HGNC symbol
- CAT
- Aliases
-
- Common name
- catalase
- Description
- This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
- Other longevity studies of this gene
- 17
- OMIM
- 115500
- Ensembl
- ENSG00000121691
- UniProt/Swiss-Prot
- CATA_HUMAN
- Entrez Gene
- 847
- UniGene
- 502302
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- ctl-2
- Caenorhabditis elegans
- ctl-3
- Caenorhabditis elegans
- ctl-1
- Danio rerio
- cat
- Drosophila melanogaster
- Cat
- Drosophila melanogaster
- CG9314
- Mus musculus
- Cat
- Rattus norvegicus
- Cat
- Saccharomyces cerevisiae
- CTA1
- Schizosaccharomyces pombe
- cta1
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as Cat
- A homolog of this gene for Mus musculus is present as Cat
- A homolog of this gene for Saccharomyces cerevisiae is present as CTA1
- GenAge human genes
- This gene is present as CAT
Christiansen et al. (2004)
Other variants which are also part of this study
