LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: Bulgarian
Study Design: Promoter -308 (G/A) SNP was examined in 17 unrelated elderly (age 65-90 years; 6 males and 11 females), 23 family members (age 18-57 years; 9 males and 14 females, and a control group with 105 randomly selected, matched for geographical distribution healthy controls aged 25-53 years (40 male and 65 female)
Conclusions: No significant differences relative to longevity were found

HGNC symbol: TNF
Aliases: DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha
Common name: tumor necrosis factor
Description: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 13
OMIM: 191160
Ensembl: ENSG00000232810
UniProt/Swiss-Prot: Q5STB3_HUMAN
Entrez Gene: 7124
UniGene: 241570
HapMap: View on HapMap

GenAge human genes

Naumova et al. (2004)