LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: Bulgarian
Study Design: Codons 10 (T/C) and 25 (G/C) SNPs were examined in 17 unrelated elderly (age 65-90 years; 6 males and 11 females), 23 family members (age 18-57 years; 9 males and 14 females), and a control group with 105 randomly selected, matched for geographical distribution healthy controls aged 25-53 years (40 male and 65 female)
Conclusions: No significant differences relative to longevity were found

HGNC symbol: TGFB1
Aliases: CED; LAP; DPD1; TGFB; TGFbeta
Common name: transforming growth factor beta 1
Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]
Other longevity studies of this gene: 17
OMIM: 190180
Ensembl: ENSG00000105329
UniProt/Swiss-Prot: TGFB1_HUMAN
Entrez Gene: 7040
UniGene: 645227
HapMap: View on HapMap

GenAge model organism genes

GenAge human genes

Naumova et al. (2004)