LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Dutch
- Study Design
- Two independent cohorts of respectively 730 and 563 subjects aged 85 and over were tested for the association of Met(410)Val SNP with longevity using a prospective follow-up design
- Conclusions
- In the first cohort, increasing Val allele frequency was found with increasing age at death. Compared to Met/Met carriers, mortality rate was reduced in Met/Val carriers in the combined cohorts. These results were not statistically significant, however.
- HGNC symbol
- SHC1
- Aliases
- SHC; SHCA
- Common name
- SHC adaptor protein 1
- Description
- This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
- Other longevity studies of this gene
- 4
- OMIM
- 600560
- Ensembl
- ENSG00000160691
- UniProt/Swiss-Prot
- SHC1_HUMAN
- Entrez Gene
- 6464
- UniGene
- 433795
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- shc-1
- Danio rerio
- shc1
- Drosophila melanogaster
- Shc
- Mus musculus
- Shc1
- Rattus norvegicus
- Shc1
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Shc1
- A homolog of this gene for Caenorhabditis elegans is present as shc-1
- GenAge human genes
- This gene is present as SHC1
Mooijaart et al. (2004)
Other variants which are also part of this study
