LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- Japanese
- Study Design
- 12 SNPs within a 10-kb region encompassing the entire SHC1 gene were examined in 230 Japanese centenarians and 180 healthy younger controls
- Conclusions
- The SNPs were not associated with longevity
- Identifier
- SHC1
- Cytogenetic Location
- 1q21.3
- UCSC Genome Browser
- View 1q21.3 on the UCSC genome browser
Gene details
- HGNC symbol
- SHC1
- Aliases
- SHC; SHCA
- Common name
- SHC adaptor protein 1
- Description
- This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
- Other longevity studies of this gene
- 4
- OMIM
- 600560
- Ensembl
- ENSG00000160691
- UniProt/Swiss-Prot
- SHC1_HUMAN
- Entrez Gene
- 6464
- UniGene
- 433795
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- shc-1
- Danio rerio
- shc1
- Drosophila melanogaster
- Shc
- Mus musculus
- Shc1
- Rattus norvegicus
- Shc1