LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Italian
- Study Design
- G/A, codon 972 polymorphism was examined in healthy people 17-85 yr of age (n= 278; mean age, 54.8; 76 males and 202 females) and in healthy people 86-109 yr of age (n= 218; mean age, 98.0; 56 males and 162 females)
- Conclusions
- No significant differences relative to longevity were found
- HGNC symbol
- IRS1
- Aliases
- HIRS-1
- Common name
- insulin receptor substrate 1
- Description
- This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]
- Other longevity studies of this gene
- 5
- OMIM
- 147545
- Ensembl
- ENSG00000169047
- UniProt/Swiss-Prot
- A0A024R499_HUMAN
- Entrez Gene
- 3667
- UniGene
- 471508
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- irs1
- Drosophila melanogaster
- chico
- Mus musculus
- Irs1
- Rattus norvegicus
- Irs1
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as chico
- A homolog of this gene for Mus musculus is present as Irs1
- GenAge human genes
- This gene is present as IRS1
- GenDR gene manipulations
- A homolog of this gene for Drosophila melanogaster is present as chico
Bonafè et al. (2003)
Other variants which are also part of this study
