LongevityMap variant

Entry Details

Longevity Association: Significant
Population: English (Cambridge)
Study Design: Allele and genotype frequencies at Hpa1 RFLP were examined in 182 women and 100 men aged >84 years and in 100 boys and 100 girls younger than 17 years
Conclusions: Allele and genotype frequencies were significantly different in the elderly women compared to the younger sample. No difference was observed in the elderly men.

HGNC symbol: APOC1
Aliases: Apo-CI; ApoC-I; apo-CIB; apoC-IB
Common name: apolipoprotein C1
Description: This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Other longevity studies of this gene: 3
OMIM: 107710
Ensembl: ENSG00000130208
UniProt/Swiss-Prot: A0A024R0T8_HUMAN
Entrez Gene: 341
UniGene: 110675
HapMap: View on HapMap

CellAge gene expression

Galinsky et al. (1997)