LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: Irish (Belfast)
Study Design: 100 control samples (59% female, 41% male with an age-range of 19-45 years old) and 93 aged samples (70% female, 30% male with an age-range of 80-97 years old) were examined for the -308A/G SNP
Conclusions: No age-related allele or genotype frequencies were observed

HGNC symbol: TNF
Aliases: DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha
Common name: tumor necrosis factor
Description: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 13
OMIM: 191160
Ensembl: ENSG00000232810
UniProt/Swiss-Prot: Q5STB3_HUMAN
Entrez Gene: 7124
UniGene: 241570
HapMap: View on HapMap

GenAge human genes

Ross et al. (2003)