LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Irish
- Study Design
- 100 control samples (59% female and 41% male) and 93 aged consecutive samples (70% female, 30% male with an age range of 80-97 years) were analyzed for Intron 1 A/T SNP
- Conclusions
- No significant differences were observed in centenarians and controls
- HGNC symbol
- CXCL8
- Aliases
- IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1
- Common name
- C-X-C motif chemokine ligand 8
- Description
- The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 2
- OMIM
- 146930
- Ensembl
- ENSG00000169429
- UniProt/Swiss-Prot
- A0A024RDA5_HUMAN
- Entrez Gene
- 3576
- UniGene
- 624
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- CXCL8
Ross et al. (2003)
Other variants which are also part of this study