LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Italian (Northern and Central)
- Study Design
- -511 C/T SNP was examined in 1131 unrelated individuals aged 20-102 years (453 females and 678 males, including 94 female and 40 male centenarians)
- Conclusions
- No significant differences in the genotype and allele frequency distributions were observed between young, elderly and centenarian subjects
- HGNC symbol
- IL1B
- Aliases
- IL-1; IL1F2; IL1-BETA
- Common name
- interleukin 1 beta
- Description
- The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 6
- OMIM
- 147720
- Ensembl
- ENSG00000125538
- UniProt/Swiss-Prot
- IL1B_HUMAN
- Entrez Gene
- 3553
- UniGene
- 126256
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- il1b
- Mus musculus
- Il1b
- Rattus norvegicus
- Il1b
- GenAge microarray genes
- This gene is present as IL1B
Cavallone et al. (2003)
Other variants which are also part of this study
