GenAge entry for NR3C1 (Homo sapiens)

Gene name (HAGRID: 75)

HGNC symbol
NR3C1 
Aliases
GR; GRL 
Common name
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

NR3C1 is a glucocorticoid receptor that modulates the expression of glucocorticoid-responsive genes. Mice with reduced NR3C1 function show behavioural changes indicative of cognitive impairment [1025], and in rats neurodegeneration has been associated with NR3C1 [1031]. A direct role in human ageing has not been demonstrated.

Cytogenetic information

Cytogenetic band
5q31.3
Location
143,277,930 bp to 143,403,689 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0006366; transcription from RNA polymerase II promoter
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0006915; apoptotic process
GO:0007059; chromosome segregation
GO:0007067; mitotic nuclear division
GO:0007165; signal transduction
GO:0016569; covalent chromatin modification
GO:0042921; glucocorticoid receptor signaling pathway
GO:0043402; glucocorticoid mediated signaling pathway
And 4 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005759; mitochondrial matrix
GO:0005815; microtubule organizing center
GO:0005819; spindle
GO:0043234; protein complex
Function: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003723; RNA binding
GO:0004883; glucocorticoid receptor activity
GO:0005496; steroid binding
GO:0005515; protein binding
GO:0008270; zinc ion binding
GO:0038051; glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity
GO:1990239; steroid hormone binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
POU1F1, TP53, TXN, NFKB2, STAT5B, STAT3, EGFR, NCOR1, CREBBP, HSP90AA1, NR3C1, NFKB1, UBE2I, CEBPA, CEBPB, EP300, PML, PRKDC, RELA, HDAC1, HSPD1, HSPA1A, JUN, MED1, HMGB1, HMGB2, CREB1, TBP, HDAC2, MDM2, SUMO1, STUB1, PPARGC1A, PPARG, NCOR2
STRING interaction network
Protein-Protein network diagram for NR3C1

Retrieve sequences for NR3C1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
nr3c1
Mus musculus
Nr3c1
Rattus norvegicus
Nr3c1

In other databases

LongevityMap
  • This gene is present as NR3C1

Selected references

External links

EPD
ORF Accession
NM_000176
CDS Accession
NP_000167
OMIM
138040
HPRD
00679
Ensembl
NR3C1
UniProt/Swiss-Prot
GCR_HUMAN
GeneCards
NR3C1
Entrez Gene
2908
GenAtlas
NR3C1
Internet
Search Google